MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening

MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3

Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism significantly contributes to cancer onset and progression. Here, we report that miR-29b negatively regulates AKT2/AKT3 expression, causing HK2/PKM2 downregulation and leading to a decreased Warburg effect and slowed ovarian cancer progression. Compared to normal ovaries, ...

miR-29b

Multiple myeloma (MM) is a heterogeneous disease originating from the transformation of a post-germinal center B cell. MM pathogenesis is a multistep process with chro-mosomal changes, genetic and epigenetic events occurring at different stages during the course of the disease. 1 MicroRNAs (miRNAs) are well known to be transcriptional repressors, possessing tumor suppressor (Ts) or oncogenic fu...

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.

MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial roles in vascular integrity. As such, they may have a role in modifying abdominal aortic aneurysm (AAA) expansion, the pathophysiological mechanisms of which remain incompletely explored. Here, we investigate the role of miRs in 2 murine models of experimental AAA: the porcine pancreatic elastase (PPE) i...

Battle of the bulge: miR-195 versus miR-29b in aortic aneurysm.

Expression Analysis of Cellular Mir-29a and mir-29b in HIV Positive Patients

Abstract        Background and Objective: Various cellular factors affect the process of HIV activity. One of these cellular factors are structures known as microRN that are expected to be involved in controlling HIV replication and infectivity. The expression of one or a set of them may represent the patient's clinical conditions. In this study, ...